Trial Characteristics | N | Trial Registered | Risk of Bias | |||
---|---|---|---|---|---|---|
 | 300 | Yes (N = 69;23%) | No (N = 231;77%) | Low (N = 23;8%) | Unclear (N = 99;33%) | High (N = 178;59%) |
Impact factor (median, range) | 294 | 4.017 (0.581-52.589) | 1.883 (0.080-15.484) | 2.948 (0.475-10.169) | 1.850 (0.329-52.589) | 2.342 (0.080-28.638) |
Continent of corresponding author | Â | Â | Â | Â | Â | Â |
   Africa | 11 | 4 (5.8) | 7 (3.0) | 1 (4.4) | 4 (4.0) | 6 (3.4) |
   Asia | 58 | 6 (8.7) | 52 (22.5) | 6 (26.1) | 27 (27.3) | 25 (14.0) |
   Australia | 16 | 1 (1.5) | 15 (6.5) | 2 (8.7) | 7 (7.1) | 7 (3.9) |
   Europe (excluding UK) | 91 | 17 (24.6) | 74 (32.0) | 6 (26.1) | 27 (27.3) | 58 (32.6) |
   North America | 87 | 30 (43.5) | 57 (24.7) | 5 (21.7) | 19 (19.2) | 63 (35.4) |
   South America | 7 | 2 (2.9) | 5 (2.2) | - | 2 (2.0) | 5 (2.8) |
   United Kingdom | 30 | 9 (13.0) | 21 (9.1) | 3 (13.0) | 13 (13.1) | 14 (7.9) |
Funding source specified | 194 | 62 (89.9) | 132 (57.1) | 23 (100.0) | 49 (49.5) | 122 (68.5) |
Industry supported | 67 | 24/62 (38.7) | 43/132 (32.6) | 7/23 (30.4) | 8/49 (16.3) | 52/122 (42.6) |
Primary outcome explicitly stated | 123 | 41 (59.4) | 82 (35.5) | 14 (60.9) | 34 (34.3) | 75 (42.1) |
Statistically significant outcome | 230 | 47 (68.1) | 183 (79.2) | 15 (65.2) | 83 (83.8) | 132 (74.2) |
Data Monitoring Committee | 14 | 9 (13.0) | 5 (2.2) | 1 (4.4) | 5 (5.1) | 8 (4.5) |
Jadad score (mean; median, range) | 300 | 2.99 (3; 0-5) | 2.44 (2; 0-5) | 3.96 (4; 3-5) | 2.24 (2; 1-5) | 2.56 (2; 0-5) |
Allocation Concealment | Â | Â | Â | Â | Â | Â |
   Adequate | 65 | 24 (34.8) | 41 (17.8) | 20 (87.0) | 15 (15.2) | 30 (16.9) |
   Unclear | 227 | 45 (65.2) | 182 (78.8) | 3 (13.0) | 84 (84.9) | 140 (78.7) |
   Inadequate | 8 | - | 8 (3.5) | - | - | 8 (4.5) |
Trial registered | 69 | NA | NA | 11 (47.8) | 10 (10.1) | 48 (27.0) |
Risk of Bias | Â | Â | Â | Â | Â | Â |
   Low | 23 | 11 (15.9) | 12 (5.2) | NA | NA | NA |
   Unclear | 99 | 10 (14.5) | 89 (38.5) |  |  |  |
   High | 178 | 48 (69.6) | 130 (56.3) |  |  |  |