Table 2 Infection and pharmacokinetic parameters of neonates treated with rifampin.
From: Use of rifampin in persistent coagulase negative staphylococcal bacteremia in neonates
N = 18 | Mean | SD | Min | Max |
|---|---|---|---|---|
Age at start of bacteremia | 5.4 | 2.7 | 1 | 11 |
Days of bacteremia before start of rifampin | 8.0 | 3.6 | 2 | 14 |
Days of vancomycin therapy before start of rifampin | 8.9 | 4.5 | 2 | 20 |
Maximum peak level of vancomycin (mg/L) | 26.7 | 3.5 | 20.0 | 32.0 |
Minimum peak level of vancomycin (mg/L) | 20.3 | 4.7 | 12.8 | 28.0 |
Maximum trough level of vancomycin (mg/L) | 10.8 | 2.6 | 7.3 | 15.9 |
Minimum trough level of vancomycin (mg/L) | 7.3 | 3.6 | 3.5 | 15.9 |
CRP at start of rifampin (mg/L) | 77.5 | 44.8 | 3 | 146 |
Maximum CRP during bacteremia (mg/L) | 120.3 | 64.4 | 9 | 250 |
Duration of rifampin therapy (hours) | 147.2 | 52.5 | 52 | 264 |
Dose of rifampin (mg/kg/day) | 10.4 | 3.0 | 6.0 | 17.0 |
Rapidity of sterilization of blood culture after start of rifampin (days) | 2.3 | 1.6 | 0 | 6 |
Total duration of bacteremia (days) | 10.3 | 3.7 | 4 | 15 |