Skip to main content

Advertisement

Table 1 Baseline characteristics of the children according to antiretroviral treatment outcome group

From: Growth, immune and viral responses in HIV infected African children receiving highly active antiretroviral therapy: a prospective cohort study

Characteristic All VS/IS** VS/IF VF/IS VF/IF P
Number (%) 124 80 (65) 27 (22) 10 (8) 7 (5)  
Sex n(%)       
   Male 63 (51) 40 (50) 13 (48) 5 (50) 5 (71)  
   Female 61 (49) 40 (50) 14 (52) 5 (50) 2 (29) 0.73†
Age (years)       
median (IQR) 5.0 (2.1- 7.0) 4.7 (2.0 -8.6) 7.0 (5.4-9.8) 1.7 (0.9 - 2.8) 4.08(1.3 -6.6) 0.0001*a
BAZ¥       
Median (IQR) 0.29 (-2.9, -1.2) 0.42 (-0.8, 0.9) -0.42 (-1.7, 0.4) 0.44 (0.2, 1.3) 0.37 (0.3, 1.0) 0.01*a
WAZ¥       
   median (IQR)‡ -1.2 (-2.1, - 0.5) -1.13 (-1.9, - 0.2) -2.10 (-2.9,-1.2) -1.33 (-2.1, -0.6) -0.90 (-1.1, -0.6) 0.06a
HAZ¥       
   median (IQR) -2.0 (-2.9, -1.2) -1.95 (-2.6, -1.1) -2.39 (-3.2, -1.42) - 2.55 (-3.7, -1.3) -1.99 (-3.2, -1.5) 0.18a
#WHO stage n (%)       
   Stage1 23 (19) 14(18) 6 (22) 2 (20) 1(14)  
   Stage 2 63 (51) 37(46) 17 (63) 5 (50) 4(57)  
   Stage 3 38 (30) 29(36) 4 (15) 3 (30) 2(29) 0.61
WAZ category‡       
   WAZ >-2 81 (72) 58 (77) 10 (48) 7 (70) 6 (100)  
   WAZ <=-2 31 (28) 17 (23) 11 (52) 3 (30) 0 (0) 0.02*
HAZ category       
   HAZ >-2 62 (50) 42 (53) 12 (44) 4 (40) 4 (57)  
   HAZ <=-2 62 (50) 38 (47) 15 (55) 6 (60) 3 (43) 0.78
BAZ category       
   BAZ >-2 117 (94) 75 (94) 25 (93) 10 (100) 7(100)  
   BAZ <=-2 7 (6) 5 (6) 2 (7) 0 (0) 0 (0) 0. 75
Log10 HIV-1 RNA       
   median (IQR) 5.55 (5.2 - 5.8) 5.54 (5.2 - 5.9) 5.36 (4.9 - 5.7) 5.88 (5.7 - 5.9) 5.76 (5.6 - 6.2) 0.007*a
CD4 cell %       
   median (IQR)§ 11.75 (7.5 - 18.0) 14.7 (10.3 -19.7) 7.2 (3.3 - 9.0) 14.6 (8.4 - 21.0) 5 (3.8 -11.1) 0.0001*a
CD4 cell % category       
n (%)       
   ≤ 5% 19 (16) 6 (8) 8 (31) 1 (10) 4 (57)  
   > 5% - ≤ 10% 30 (25) 13 (17) 13 (50) 3 (30) 1 (14)  
   > 10% 71 (59) 58 (75) 5 (19) 6 (60) 2 (29) < .0001*
  1. a Kruskal Wallis tests for p values and others based on Pearson Chi-squared test *Statistically significant at the 0.05 alpha level ‡n = 112 because 12 children >10 yrs #according to WHO paediatric clinical staging 2003 §4 missing CD4 cell percents at baseline. ¥BAZ = basal metabolic rate z score, ¥WAZ = weight for age z score, ¥HAZ = height for age z score. **VS = virological success, IS = immunological success, VF = virological failure, IF = immunological failure.