Children < 20 kg | Children ≥20 kg | ||||
---|---|---|---|---|---|
Category | Esomeprazole 5 mg (0.3-0.6 mg/kg) (n = 26) | Esomeprazole 10 mg (0.6-1.0 mg/kg) (n = 23) | Esomeprazole 10 mg (0.2-0.5 mg/kg) (n = 31) | Esomeprazole 20 mg (0.3-1.0 mg/kg) (n = 29) | Total (N = 109) |
Eosinophilic densification | 4 (15) | 3 (13) | 8 (26) | 12 (41) | 27 (25) |
Intraepithelial eosinophils† | 5 (19) | 9 (39) | 13 (42) | 13 (45) | 40 (37) |
Intraepithelial neutrophils† | 5 (19) | 1 (4) | 6 (19) | 3 (10) | 15 (14) |
Intraepithelial lymphocytes† | 13 (50) | 9 (39) | 17 (55) | 14 (48) | 53 (49) |
Elongated length of papillae | 16 (62) | 10 (44) | 16 (52) | 19 (66) | 61 (56) |
Increased thickness of basal cell layer | 15 (58) | 13 (56) | 15 (48) | 19 (66) | 62 (57) |
Increased total epithelial thickness | 11 (42) | 10 (44) | 10 (32) | 10 (34) | 41 (38) |
Dilation of intercellular spaces | |||||
Absent/NR | 21 (81) | 21 (91) | 24 (77) | 17 (59) | 83 (76) |
< 25% | 3 (12) | 2 (9) | 5 (16) | 10 (34) | 20 (18) |
≥25% | 2 (8) | 0 | 2 (6) | 2 (7) | 6 (6) |
Columnar epithelium | |||||
Present | 4 (15) | 4 (17) | 3 (10) | 4 (14) | 15 (14) |
Not assessable | 1 (4) | 5 (22) | 7 (23) | 4 (14) | 17 (16) |
Cardia mucosa | 2 (8) | 3 (13) | 1 (3) | 4 (14) | 10 (9) |
Corpus mucosa | 1 (4) | 1 (4) | 3 (10) | 1 (3) | 6 (6) |
Diagnosis of microscopic reflux esophagitis | 20 (77) | 18 (78) | 24 (77) | 24 (83) | 86 (79) |