Table 2 Demographic and baseline disease characteristics of all patients enrolled (N = 109)
Children < 20 kg | Children ≥ 20 kg | |||
|---|---|---|---|---|
Characteristic | Esomeprazole 5 mg (0.3-0.6 mg/kg) (n = 26) | Esomeprazole 10 mg (0.6-1.0 mg/kg) (n = 23) | Esomeprazole 10 mg (0.2-0.5 mg/kg) (n = 31) | Esomeprazole 20 mg (0.3-1.0 mg/kg) (n = 29) |
Girls, n (%) | 14 (53.8) | 14 (60.9) | 14 (45.2) | 11 (37.9) |
Mean age, years | 2.1 | 2.5 | 8.5 | 8.3 |
Age in years, n (%) | ||||
1 | 12 (46.2) | 8 (34.8) | ||
2 | 6 (23.1) | 5 (21.7) | ||
3 | 4 (15.4) | 4 (17.4) | ||
4 | 2 (7.7) | 3 (13.0) | 1 (3.2) | 2 (6.9) |
5 | 1 (3.8) | 2 (8.7) | 1 (3.2) | 1 (3.4) |
6 | 1 (3.8) | 1 (4.3) | 2 (6.5) | 0 |
7 | 5 (16.1) | 3 (10.3) | ||
8 | 5 (16.1) | 9 (31.0) | ||
9 | 8 (25.8) | 6 (20.7) | ||
10 | 3 (9.7) | 6 (20.7) | ||
11 | 6 (19.4) | 2 (6.9) | ||
Race, n (%) | ||||
White | 19 (73.1) | 19 (82.6) | 26 (83.9) | 25 (86.2) |
Black | 7 (26.9) | 4 (17.4) | 5 (16.1) | 3 (10.3) |
Other | 0 | 0 | 0 | 1 (3.4) |
Mean height (range), cm | 90.0 (70-109) | 94.2 (80-119) | 134.5 (108-168) | 134.5 (112-159) |
Mean weight (range), kg | 12.8 (8-18) | 14.1 (10-18) | 35.5 (20-58) | 34.5 (21-60) |
Mean body mass index (SD), kg/m2 | 15.7 (2.1) | 15.9 (1.7) | 19.3 (4.8) | 18.6 (3.9) |
Helicobacter pylori-positive, n (%) | 0 | 1 (4.3) | 0 | 0 |
Symptoms at baseline, n (%) | ||||
Heartburn | 15 (57.7) | 10 (43.5) | 19 (61.3) | 13 (44.8) |
Acid regurgitation | 18 (69.2) | 11 (47.8) | 20 (64.5) | 11 (37.9) |
Epigastric pain | 17 (65.4) | 13 (56.5) | 15 (48.4) | 15 (51.7) |
Vomiting | 13 (50.0) | 7 (30.4) | 3 (9.7) | 5 (17.2) |
Eating difficulties | 15 (57.7) | 13 (56.5) | 9 (29.0) | 7 (24.1) |
Difficulty swallowing | 6 (23.1) | 8 (34.8) | 5 (16.1) | 6 (20.1) |
Extraesophageal symptoms at baseline, n (%) | n = 12 | n = 12 | n = 16 | n = 13 |
Hoarseness | 4 (33.3) | 4 (50.0) | 4 (25.0) | 7 (53.8) |
Coughing | 8 (66.7) | 9 (75.0) | 7 (43.8) | 7 (53.8) |
Gagging | 5 (41.7) | 6 (50.0) | 2 (12.5) | 4 (30.8) |
Wheezing/stridor | 1 (8.3) | 1 (8.3) | 2 (12.5) | 0 (0) |
Mean (range) esomeprazole dose, mg/kg | 0.4 (0.3-0.6) | 0.7 (0.6-1.0) | 0.3 (0.2-0.5) | 0.6 (0.3-1.0) |