From: Do pneumococcal conjugate vaccines provide any cross-protection against serotype 19A?
Study or Analysis | Vaccine | Vaccine regimen | Endpoint | Age group | Total Number of Subjects | Numbers of 19F Cases | % VE against 19F (95% CI) | Numbers of 19A Cases | % VE against 19A (95% CI) |
---|---|---|---|---|---|---|---|---|---|
Polysaccharide vaccine | IPD | Â | Â | Â | Â | Â | Â | ||
US indirect cohort analysis [37] | PS14-V* | 1 dose as per US recomm. | IPD | > 5 y | 2837 total cases | 12 (vacc) 32(unvacc) | 11 (-86,,56) | 10 (vacc) 42(unvacc) | 44 (-21, 74) |
Conjugate vaccines | IPD | Â | Â | Â | Â | Â | Â | ||
7vCRM | 2,4,6,12-15 mo | IPD after ≥ 3 doses | 2 mo to ~3.5 y | 18927 (vacc) 18941 (ctrl) | 2 (vacc) 13 (ctrl) | 85 (32, 97) | 0 (vacc) 1 (ctrl) | 67 (-719, 99) | |
Native Americans efficacy | 7vCRM | 2,4,6,12-15 mo | IPD after ≥ 3 doses | 2 mo to 2 y | 7532 (vacc) 7151 (ctrl) | 0 (vacc) 1 (ctrl) | 68 (-677, 99) | 1 (vacc) 0(ctrl) | -185 (-900, 88) |
9vCRM | 6, 10, 14 wks | IPD after 3 doses | 6 wk to 6.2 y | 18633 (vacc) 18626 (ctrl) | 0 (vacc) 1 (ctrl) | 67 (-718, 99) | 3 (vacc) 1 (ctrl) | -200 (-900, 69) | |
9vCRM | 6, 10, 14 wks | IPD after 3 doses | 6 wk to 6.2 y | 1289 (vacc) 1288 (ctrl) | 5 (vacc) 3 (ctrl) | -67 (-595,60) | 3 (vacc) 6 (ctrl) | 50 (-99, 88) | |
Gambia efficacy | 9vCRM | 6, 10, 14 wks | IPD after 3 doses | 6 wk to 2.9 y | 8718 (vacc) 8719 (ctrl) | 0 (vacc) 2 (ctrl) | 80 (-317, 99) | 6 (vacc) 7 (ctrl) | 14 (-155, 71) |
Meta-analysis of preceding efficacy studies(a) | 7vCRM & 9vCRM | see individual studies | 55099 (vacc) 54725 (ctrl) | 7 (vacc) 20 (ctrl) | 61 (13, 82) | 13 (vacc) 15 (ctrl) | 13 (-79, 58) | ||
US post-marketing surveillance [19] | 7vCRM | 2,4,6,12-15 mo; catch-up schedule for < 2 y | IPD (2nd yr after launch) | > 2 y (not all vacc) | ~433,000 | 79 (pre) 14 (post) | 83 (72, 90) (% decrease decrease in estimated rate from pre-7vCRM) | 20 (pre) 12 (post) | 40 (-5, 68) (% decrease in estimated rate from pre-7vCRM) |
US CDC case-control [9] | 7vCRM | 2,4,6,12-15 mo | IPD ≥ 1 dose | 3 to 59 mo | n.a. | 34 discordant sets | 87 (65, 95) | 46 discordant sets | 26 (-45, 62) |
Canada (Québec) [40]: case-control | 7vCRM | 2,4,12 mo | IPD ≥ 1 dose | <5 y | n.a. | 3 (vacc); 8 (unvacc) | 93 (61,99) | 29 (vacc); 8 (unvacc) | 42 (-76, 79) |
Conjugate Vaccines | AOM | Â | Â | Â | Â | Â | Â | ||
Finland [10]: efficacy (FinOM) | 7vCRM | 2,4,6,12 mo | AOM after ≥ 3 doses | 6.5 to 24 mo | 831 (vacc) 831 (ctrl) | 43 (vacc) 58 (ctrl) | 25 (-14, 51) | 17 (vacc) 26 (ctrl) | 34 (-26, 65) |
Finland [41]: efficacy(FinOM) | 7vOMP | 2,4,6,12 mo | AOM after ≥ 3 doses | 6.5 to 24 mo | 831 (vacc) 831 (ctrl) | 37 (vacc) 58 (ctrl) | 37 (1, 59) | 22 (vacc) 26 (ctrl) | 16 (-53, 54) |
Czech/Slovak [11]: efficacy (POET) | 11Pn-PD | 3,4,5,12-15 mo | AOM after ≥ 3 doses | 5 to 27 mo | 2489 (vacc) 2479 (ctrl) | 24 (vacc) 43 (ctrl) | 44 (8, 66) | 1 (vacc) 3 (ctrl) | 67 (-209, 97) |