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Table 7 Diagnostic performance of study measurements for culture positive infection

From: A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection

Culture positive infection

 

All

Early onset

Late Onset

Preterm

Term

sICAM-1

n = 40

n = 5

n = 35

n = 33

n = 7

AUC

0.78

0.57

0.65

0.81

0.56

Optimum cut off

249 ng/ml

228 ng/ml

504 ng/ml

249 ng/ml

170 ng/ml

sensitivity

77.5%

40.0%

48.6%

87.9%

71.4%

specificity

66.9%

93.0%

79.0%

60.0%

55.3%

Positive predictive value

38.7%

25.0%

56.7%

39.7%

22.7%

Negative predictive value

91.7%

96.4%

73.1%

94.3%

91.3%

hsCRP

n = 40

n = 6

n = 34

n = 32

n = 8

AUC

0.78

0.81

0.71

0.79

0.72

Optimum cut off

0.6 mg/l

0.6 mg/l

0.6 mg/l

0.6 mg/l

0.4 mg/l

sensitivity

80%

83.3%

79.4%

81.2%

87.5%

specificity

71.4%

80.2%

59.0%

73.6%

59.5%

Positive predictive value

43.2%

22.7%

51.9%

47.3%

31.8%

Negative predictive value

92.9%

98.6%

83.7%

93.1%

95.7%

SAA

n = 36

n = 5

n = 31

n = 29

n = 7

AUC

0.68

0.74

0.67

0.68

0.65

Optimum cut off

1 mg/l

1 mg/l

0.9 mg/l

3 mg/l

1 mg/l

sensitivity

63.9%

80.0%

77.4%

41.4%

85.7%

specificity

64.3%

47.0%

46.7%

86.9%

55.6%

Positive predictive value

31.1%

12.5%

42.9%

46.2%

27.3%

Negative predictive value

87.6%

98.2%

80.0%

84.5%

95.2%

sE-selectin

n = 33

n = 5

n = 28

n = 27

n = 6

AUC

0.72

0.77

0.66

0.79

0.52

Optimum cut off

132 mg/l

162 mg/l

116 mg/l

132 mg/l

224 mg/l

sensitivity

63.6%

60.0%

67.9%

66.7%

33.3%

specificity

76.0%

90.3%

62.3%

79.4%

87.9%

Positive predictive value

41.2%

30.0%

48.7%

48.6%

40.0%

Negative predictive value

88.8%

97.0%

78.6%

89.0%

88.2%

  1. Culture positive infected infants: Area under curve (AUC), optimum diagnostic "cut off" level and diagnostic performance statistics derived from ROC curve analysis for each test measurement for culture positive infected infants and subcategories defined as early/late onset symptoms, and preterm/term infants.