A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection

Table 5 Study measurements in the clinical groups excluding repeat samples

Clinical group	Controls (n = 13)	Not Infected (n = 89)	Infected (n = 46)
				Culture positive (n = 26)	Culture Negative (n = 20)
sICAM-1 (ng/ml),	155 (118,228)	164 (138,200)	300 (198,488) P < 0.001	346 (215,568) P < 0.001	268 (190,339) P < 0.001
hsCRP(mg/l),	0.1 (0.1,0.25)	0.1 (0.1,1.0)	1.0 (0.4,15.8) P < 0.001	1.6 (0.7,20.0) P < 0.001	0.85 (0.1,6.0) P = 0.017
SAA(mg/l)	0.9 (0.9,1.0)	1.0 (0.9,2.0)	2.0 (0.9,4.8) P = 0.021	2.0 (0.9-5.8) P = 0.007	1.0 (0.9,2.8) P > 0.05
sE-selectin(ng/ml)	61 (52,101)	82 (58,120)	104 (84,176) P < 0.001	150 (93,196) P < 0.001	98 (63,150) P > 0.05

Results excluding repeat samples from individual infants. Only the first episode is included for each infant. Levels of test measurements in each clinical group and duration of antibiotic therapy is provided. All data quoted as (median, (1^st, 3^rd quartiles)). Statistical comparison between infected and not infected groups (Mann Whitney U test). Highly significant elevations (P < 0.001) highlighted in bold. Control samples not included in statistical analysis.

ISSN: 1471-2431