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  1. Study protocol

    Towards evidence-based vitamin D supplementation in infants: vitamin D intervention in infants (VIDI) — study design and methods of a randomised controlled double-blinded intervention study

    Vitamin D is important for bone mass accrual during growth. Additionally, it is considered a requirement for a multitude of processes associated with, for example, the development of immunity. Many countries a...

    Otto Helve, Heli Viljakainen, Elisa Holmlund-Suila, Jenni Rosendahl, Helena Hauta-alus, Maria Enlund-Cerullo, Saara Valkama, Kati Heinonen, Katri Räikkönen, Timo Hytinantti, Outi Mäkitie and Sture Andersson

    BMC Pediatrics 2017 17:91

    Published on: 29 March 2017

  2. Research article

    Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins

    Previous studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic encephalopathy (HIE), and melatonin may exhibit neuro-protection against brain insults. However, little i...

    Li-Xiao Xu, Yuan Lv, Yan-Hong Li, Xin Ding, Ying Wang, Xing Han, Ming-Hua Liu, Bin Sun and Xing Feng

    BMC Pediatrics 2017 17:90

    Published on: 28 March 2017

  3. Technical advance

    Simultaneous detection of respiratory syncytial virus and human metapneumovirus by one-step multiplex real-time RT-PCR in patients with respiratory symptoms

    Both respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are important viral pathogens causing respiratory tract infection (RTI) in the pediatric population. However, the clinical manifestations...

    Huey-Ling You, Shun-Jen Chang, Hong-Ren Yu, Chia-Chin Li, Chang-Han Chen and Wei-Ting Liao

    BMC Pediatrics 2017 17:89

    Published on: 27 March 2017

  4. Research article

    Factors associated with anemia among Sri Lankan primary school children in rural North Central Province

    Despite interventions, childhood anemia is still a major public health problem in low and middle income countries. Purpose of the present study is to determine factors associated with anemia among rural primar...

    Gayani Shashikala Amarasinghe, Naotunna Palliya Guruge Chamidri Randika Naottunna, Thilini Chanchala Agampodi and Suneth Buddhika Agampodi

    BMC Pediatrics 2017 17:87

    Published on: 27 March 2017

  5. Research article

    Does sevoflurane add to outpatient procedural sedation in children? A randomised clinical trial

    There is little evidence concerning the effect of sevoflurane in outpatient procedural sedation, especially in children. We hypothesised that the addition of sevoflurane to a sedation regimen improves children...

    Hugo Sérgio de Oliveira Gomes, Heloisa de Sousa Gomes, Joji Sado-Filho, Luciane Rezende Costa and Paulo Sucasas Costa

    BMC Pediatrics 2017 17:86

    Published on: 24 March 2017

  6. Research article

    Incidence and time trends of type 2 diabetes mellitus in youth aged 5–19 years: a population-based registry in Zhejiang, China, 2007 to 2013

    The incidence of type 2 diabetes mellitus (T2DM) has been increasing globally over the past two decades in children and adolescents. There are currently a dearth of comprehensive population-based estimates of ...

    Haibin Wu, Jieming Zhong, Min Yu, Hao Wang, Weiwei Gong, Jin Pan, Fangrong Fei, Meng Wang, Li Yang and Ruying Hu

    BMC Pediatrics 2017 17:85

    Published on: 22 March 2017

  7. Research article

    Slow progress in diarrhea case management in low and middle income countries: evidence from cross-sectional national surveys, 1985–2012

    Diarrhea remains to be a main cause of childhood mortality. Diarrhea case management indicators reflect the effectiveness of child survival interventions. We aimed to assess time trends and country-wise change...

    Chandrashekhar T. Sreeramareddy, Yue-Peng Low and Birger Carl Forsberg

    BMC Pediatrics 2017 17:83

    Published on: 21 March 2017

  8. Research article

    Characterizing early child growth patterns of height-for-age in an urban slum cohort of Bangladesh with functional principal component analysis

    Early childhood is a critical stage of physical and cognitive growth that forms the foundation of future wellbeing. Stunted growth is presented in one of every 4 children worldwide and contributes to developme...

    Yin Zhang, Jianhui Zhou, Feiyang Niu, Jeffrey R. Donowitz, Rashidul Haque, William A. Petri and Jennie Z. Ma

    BMC Pediatrics 2017 17:84

    Published on: 21 March 2017

  9. Research article

    Population-based study of the incidence of congenital hip dysplasia in preterm infants from the Survey of Neonates in Pomerania (SNiP)

    Some etiological factors involved in developmental dysplasia of the hip (DDH) occur in the last trimester of pregnancy, which could result in a decreased incidence of DDH in preterm infants. The aim of this st...

    A. E. Lange, J. Lange, Till Ittermann, M. Napp, Paul-Christian Krueger, H. Bahlmann, R. Kasch and M. Heckmann

    BMC Pediatrics 2017 17:78

    Published on: 16 March 2017

  10. Case report

    Near-infrared spectroscopy as a predictor of clinical deterioration: a case report of two infants with duct-dependent congenital heart disease

    Some infants with congenital heart disease are at risk of in-hospital cardiac arrest. To better foresee cardiac arrest in infants with congenital heart disease, it might be useful to continuously assess end-or...

    Mirthe J. Mebius, Gideon J. du Marchie Sarvaas, Diana W. Wolthuis, Beatrijs Bartelds, Martin C. J. Kneyber, Arend F. Bos and Elisabeth M. W. Kooi

    BMC Pediatrics 2017 17:79

    Published on: 16 March 2017

  11. Research article

    Thermal quantitative sensory testing in healthy Dutch children and adolescents standardized test paradigm and Dutch reference values

    Quantitative sensory testing (QST) is often used to measure children’s and adults’ detection- and pain thresholds in a quantitative manner. In children especially the Thermal Sensory Analyzer (TSA-II) is often...

    Gerbrich E. van den Bosch, Monique van Dijk, Dick Tibboel and Abraham J. Valkenburg

    BMC Pediatrics 2017 17:77

    Published on: 16 March 2017

  12. Research article

    School-time physical activity among Arab elementary school children in Qatar

    Recent data from a self-administered questionnaire show that approximately 75% of school children in Qatar do not meet the daily recommended levels of physical activity (PA). Since children spend half of their...

    Lena Zimmo, Abdulaziz Farooq, Fuad Almudahka, Izzeldin Ibrahim and Mohamed Ghaith Al-Kuwari

    BMC Pediatrics 2017 17:76

    Published on: 15 March 2017

  13. Research article

    Evaluation of sublingual microcirculation in a paediatric intensive care unit: prospective observational study about its feasibility and utility

    Evaluation of the microcirculation in critically ill patients is usually done by means of indirect parameters. The aim of our study was to evaluate the functional state of the microcirculation by direct visual...

    Rafael González, Jorge López, Javier Urbano, María José Solana, Sarah Nicole Fernández, María José Santiago and Jesús López-Herce

    BMC Pediatrics 2017 17:75

    Published on: 15 March 2017

  14. Case report

    Carnitine-related hypoglycemia caused by 3 days of pivalate antibiotic therapy in a patient with severe muscular dystrophy: a case report

    Long-term treatment with antibiotics containing pivalic acid may decrease serum carnitine concentration and can sometimes be associated with severe hypoglycemia and encephalopathy in infants. Little has been r...

    Masanori Ito, Mitsumasa Fukuda, Yuka Suzuki, Hiroyuki Wakamoto and Eiichi Ishii

    BMC Pediatrics 2017 17:73

    Published on: 14 March 2017

  15. Research article

    Laparoscopic resection of neuroblastomas in low- to high-risk patients without image-defined risk factors is safe and feasible

    Several studies have reported that minimally invasive surgery (MIS) might be considered for resecting neuroblastomas without image-defined risk factors (IDRFs); however, there are no studies comparing the outc...

    Chiyoe Shirota, Takahisa Tainaka, Hiroo Uchida, Akinari Hinoki, Kosuke Chiba and Yujiro Tanaka

    BMC Pediatrics 2017 17:71

    Published on: 14 March 2017

  16. Research article

    Congenital malformations and medical conditions associated with orofacial clefts in children in Burkina Faso

    Orofacial clefts are usually isolated cases but can be associated with other congenital malformations that are either recognised or unrecognised syndromes. The reported prevalence and pattern of such associate...

    Kisito Nagalo, Isso Ouédraogo, Jean-Martin Laberge, Louise Caouette-Laberge and Jean Turgeon

    BMC Pediatrics 2017 17:72

    Published on: 14 March 2017

  17. Research article

    Correlates of thymus size and changes during treatment of children with severe acute malnutrition: a cohort study

    The impairment of immune functions associated with malnutrition may be one reason for the high mortality in children with severe acute malnutrition (SAM), and thymus atrophy has been proposed as a marker of th...

    Maren Johanne Heilskov Rytter, Hanifa Namusoke, Christian Ritz, Kim F. Michaelsen, André Briend, Henrik Friis and Dorthe Jeppesen

    BMC Pediatrics 2017 17:70

    Published on: 14 March 2017

  18. Research article

    Social inclusion for children with hearing loss in listening and spoken Language early intervention: an exploratory study

    Social inclusion is a common focus of listening and spoken language (LSL) early intervention for children with hearing loss. This exploratory study compared the social inclusion of young children with hearing ...

    Gabriella Constantinescu-Sharpe, Rebecca L. Phillips, Aleisha Davis, Dimity Dornan and Anthony Hogan

    BMC Pediatrics 2017 17:74

    Published on: 14 March 2017

  19. Research article

    Performance and reproducibility on shuttle run test between obese and non-obese children: a cross-sectional study

    Due to the increasing prevalence of obesity among children, Shuttle Run Test (SRT) has been used as primary outcome for assessment of both physical performance and responses to different physical training prog...

    Cristiane A. Moran, Maria Stella Peccin, Maria Teresa Bombig, Silvana Alves Pereira and Simone Dal Corso

    BMC Pediatrics 2017 17:68

    Published on: 9 March 2017

  20. Research article

    Somatic growth in the first six months of life of infants exposed to maternal smoking in pregnancy

    Some studies suggest a relationship between maternal smoking during pregnancy and not only intrauterine fetal growth restriction or low birth weight, but also with changes in the postnatal growth and developme...

    Mariana Lopes de Brito, Marina Nunes, Juliana Rombaldi Bernardi, Vera Lúcia Bosa, Marcelo Zubaran Goldani and Clécio Homrich da Silva

    BMC Pediatrics 2017 17:67

    Published on: 9 March 2017

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