A prospective observational study to assess the diagnostic accuracy of clinical decision rules for children presenting to emergency departments after head injuries (protocol): the Australasian Paediatric Head Injury Rules Study (APHIRST)
- Franz E Babl1, 2, 3, 4, 19Email author,
- Mark D Lyttle1, 5, 6,
- Silvia Bressan1, 2, 7,
- Meredith Borland8,
- Natalie Phillips9,
- Amit Kochar10,
- Stuart R Dalziel11, 12,
- Sarah Dalton13,
- John A Cheek1, 2, 14,
- Jeremy Furyk15,
- Yuri Gilhotra16,
- Jocelyn Neutze17,
- Brenton Ward2,
- Susan Donath2, 3,
- Kim Jachno2, 3,
- Louise Crowe2, 3,
- Amanda Williams2, 3 and
- Ed Oakley1, 2, 3
© Babl et al.; licensee BioMed Central Ltd. 2014
Received: 4 May 2014
Accepted: 27 May 2014
Published: 13 June 2014
Head injuries in children are responsible for a large number of emergency department visits. Failure to identify a clinically significant intracranial injury in a timely fashion may result in long term neurodisability and death. Whilst cranial computed tomography (CT) provides rapid and definitive identification of intracranial injuries, it is resource intensive and associated with radiation induced cancer. Evidence based head injury clinical decision rules have been derived to aid physicians in identifying patients at risk of having a clinically significant intracranial injury. Three rules have been identified as being of high quality and accuracy: the Canadian Assessment of Tomography for Childhood Head Injury (CATCH) from Canada, the Children’s Head Injury Algorithm for the Prediction of Important Clinical Events (CHALICE) from the UK, and the prediction rule for the identification of children at very low risk of clinically important traumatic brain injury developed by the Pediatric Emergency Care Applied Research Network (PECARN) from the USA. This study aims to prospectively validate and compare the performance accuracy of these three clinical decision rules when applied outside the derivation setting.
This study is a prospective observational study of children aged 0 to less than 18 years presenting to 10 emergency departments within the Paediatric Research in Emergency Departments International Collaborative (PREDICT) research network in Australia and New Zealand after head injuries of any severity. Predictor variables identified in CATCH, CHALICE and PECARN clinical decision rules will be collected. Patients will be managed as per the treating clinicians at the participating hospitals. All patients not undergoing cranial CT will receive a follow up call 14 to 90 days after the injury. Outcome data collected will include results of cranial CTs (if performed) and details of admission, intubation, neurosurgery and death. The performance accuracy of each of the rules will be assessed using rule specific outcomes and inclusion and exclusion criteria.
This study will allow the simultaneous comparative application and validation of three major paediatric head injury clinical decision rules outside their derivation setting.
The study is registered with the Australian New Zealand Clinical Trials Registry (ANZCTR)- ACTRN12614000463673 (registered 2 May 2014).
KeywordsHead injury Clinical decision rule Computed tomography Validation
Children with clinically significant intracranial injuries require urgent identification to prevent further damage to the brain. Cranial computed tomography (CT) scans provide rapid and definitive identification of the presence or absence of intracranial injuries, and help guide subsequent management. Positive results allow early intervention and optimise outcomes whilst negative results are reassuring and may allow accelerated discharge and reduce unnecessary admissions.
However, cranial CT scans also have negative effects, particularly in children, who are more vulnerable to radiation-associated cell damage . Radiation from cranial CT scans can cause lethal malignancies with higher risk in younger age groups [1–4]. Children may require sedation to allow imaging with consequent sedation-associated risks [5, 6]. They also have resource implications for Emergency Departments (EDs) and the health system as a whole . Despite this, the number of cranial CT scans performed for head injuries in children has increased in a number of countries [8–11]. This increase is likely due to a combination of easier access to CT scanners and more efficient technology and concern amongst physicians of being unable to reliably identify intracranial injury based solely on a child’s clinical condition. One way of increasing clinical sensitivity and specificity (i.e. minimising both missed clinically significant intracranial injuries and unnecessary investigations) is to develop and use clinical decision rules (CDRs).
PECARN <2 years
PECARN ≥2 years
Mechanism of injury
Dangerous mechanism of injury (eg MVC, fall from elevation ≥3 ft [≥0.91 m] or 5 stairs, fall from bicycle with no helmet).
High speed RTA as pedestrian, cyclist, occupant (>40 miles/h or >64 km/h).
Severe mechanism of injury (MVC with patient ejection, death of another passenger or rollover; pedestrian/bicyclist without helmet struck by motorized vehicle; falls >0.9 m; head struck by high impact object).
Severe mechanism of injury (MVC with patient ejection, death of another passenger or rollover; pedestrian/bicyclist without helmet struck by motorized vehicle; falls >1.5 m; head struck by high impact object).
Fall of > 3 m in height.
High speed injury from projectile or object.
Witnessed LOC > 5 min.
LOC ≥5 seconds.
Amnesia (antegrade or retrograde) >5 min.
Altered mental status.
Altered mental status.
Not acting normally per parent.
≥3 vomits after head injury (discrete episodes).
History of vomiting.
Suspicion of NAI.
Seizure in patient with no history of epilepsy.
History of worsening headache.
GCS <15, 2 hr after injury.
GCS <14, or <15 if <1 yr.
GCS < 15
GCS < 15
Irritability on examination.
Abnormal drowsiness (in excess of that expected by examining doctor).
Other signs of altered mental status (agitation, somnolence, repetitive questioning, slow response to verbal communication)
Other signs of altered mental status (agitation, somnolence, repetitive questioning, slow response to verbal communication)
Suspected open or depressed skull fracture.
Suspicion of penetrating or depressed skull injury, or tense fontanelle.
Any sign of basal skull fracture (eg haemotympanum, “raccoon” eyes, otorrhoea/rhinorrhoea of CSF, Battle’s sign).
Signs of basal skull fracture.
Palpable or unclear skull fracture.
Clinical signs of basilar skull fracture.
Positive focal neurology.
Large boggy haematoma of the scalp.
Presence of bruise, swelling or laceration > 5 cm if < 1 yr old.
Occipital, parietal or temporal scalp haematoma.
All of the following:
• Blunt trauma to head resulting in witnessed LOC/disorientation, definite amnesia, persistent vomiting (>1 episode), persistent irritability (in children <2 yrs)
• Obvious penetrating skull injury
• Obvious depressed fracture
• Acute focal neurologic deficit
• Chronic generalized developmental delay
• Head injury secondary to suspected child abuse
• Initial GCS in ED ≥13 as determined by treating physician
• Returning for reassessment of previously treated head injury
• Injury within the past 24 hours.
• Patients who were pregnant
Any history or signs of injury to the head.
Refusal to consent
Present within 24 hours of head injury.
• Trivial head injury (defined by ground level fall, walking/running into stationary object, no signs or symptoms of head trauma except scalp abrasions and lacerations).
• Penetrating trauma
• Known brain tumour
• Pre-existing neurological disorder complicating assessment
• Neuro-imaging at another hospital before transfer
• Patient with ventricular shunt*
• Patient with bleeding disorder*
• GCS < 14*
Need for neurological intervention, defined as death within 7 days secondary to the head injury or need for any of the following within 7 days: craniotomy, elevation of skull fracture, monitoring of intracranial pressure, insertion of endotracheal tube for the management of head injury
Brain injury on CT, defined as any acute intracranial finding revealed on CT attributable to acute injury, including closed depressed skull fracture (depressed past the inner table) and pneumocephalus but excluding non-depressed skull fractures and basilar skull fractures
Clinically significant intracranial injury (CSII), defined as death as a result of head injury, requirement for neurosurgical intervention, marked abnormality on CT (any new, acute, traumatic intracranial pathology as reported by consultant radiologist, including intracranial haematomas of any size, cerebral contusion, diffuse cerebral oedema and depressed skull fractures)
Presence of skull fracture Admission to hospital
Clinically important traumatic brain injury (ciTBI), defined as death from TBI, neurosurgical intervention for TBI (intracranial pressure monitoring, elevation of depressed skull fracture, ventriculostomy, haematoma evacuation, lobectomy, tissue debridement, dura repair, other), intubation of more than 24 h for TBI or hospital admission of 2 nights or more for TBI* in association with TBI on CT**
PECARN’s is the only CDR which has been internally  and externally  validated. A CATCH validation study has been performed in the derivation setting though results are only available in abstract form at present . Recently the three CDRs have been prospectively validated in the same cohort of 1,009 children presenting to an urban medical center with a designated paediatric ED in the United States. This study showed that baseline physician ordering practice and PECARN outperformed the other CDRs. However, the study population did not reflect the exact population for which each rule was originally developed and the study was underpowered to determine narrow confidence intervals for rare but critically important events .
We propose to validate and compare the accuracy of the CATCH, CHALICE and PECARN CDRs using prospectively collected data from 20,000 patients in a multicentre setting in Australia and New Zealand, i.e. outside the countries where these CDRs were derived, and compare their performance against that of our current practice. Triggers for cranial CT use by clinicians in paediatric EDs in Australia and New Zealand are different from the triggers developed in CATCH, CHALICE and PECARN . This study will also help determine which CDR is best suited for use in the Australian and New Zealand setting before incorporating them into local practice.
This is a multi-centre prospective observational study of consecutive children presenting with head injuries to paediatric EDs. All data points necessary for analysis including predictor variables and outcome data for the three clinical rules under investigation (Tables 1, 2 and 3) will be collected for all patients but treating clinicians will manage patients as per their usual practice. The study has been registered with the Australian New Zealand Clinical Trials Registry (ACTRN12614000463673). The study follows the STAndards for the Reporting of Diagnostic accuracy studies (STARD) guidelines .
The study is taking place at 9 tertiary paediatric EDs, and 1 large combined adult and paediatric ED in Australia and New Zealand. These centres are members of the Paediatric Research in Emergency Departments International Collaborative (PREDICT) : in New Zealand Kidz First Children’s Hospital, Auckland, and Starship Children’s Hospital, Auckland; in Australia Monash Medical Centre, Clayton, VIC, Children’s Hospital at Westmead, Sydney, NSW, Royal Children’s Hospital, Melbourne, VIC, Royal Children’s Hospital, Brisbane, QLD, Mater Children’s Hospital, Brisbane, QLD, Princess Margaret Hospital for Children, Perth, WA, Women’s & Children’s Hospital, Adelaide, SA, and Townsville Hospital, Townsville, QLD. The annual paediatric census of the 10 participating EDs is >400,000. The central site for the study is the Murdoch Children’s Research Institute, which is affiliated with the Royal Children’s Hospital Melbourne.
Patients less than 18 years of age with head injuries of all severities irrespective of length of time from injury to presentation will be included. The definition of head injury does not include patients who have sustained a trivial facial injury (ground level fall or walking or running into an object with no signs or symptoms of injury other than facial abrasions or lacerations below the eyebrows).
We will exclude patients and families who refuse to participate, are being referred directly from ED triage to a general practitioner or other external provider (i.e. not seen in the ED), or who do not wait to be seen. We will exclude from analysis patients with neuroimaging prior to transfer (Figure 1). Individual exclusion criteria (relevant to each CDR (Table 2)) will be applied during analysis.
Primary outcome measure
Primary outcome will be the performance accuracy (sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV)) of each CDR in identifying rule specific outcomes (Table 3) when applied to those patients who meet the individual inclusion and exclusion criteria (Table 2).
Secondary outcome measures
Rate of neurosurgical intervention in the study population.
Rate of cranial CT use in the study population.
Number of missed ciTBI and CSII in the study population.
Characteristics of missed significant intracranial injuries that would have been identified by the application of each CDR to the study population.
Number of extra cranial CT scans that would be performed by applying each CDR.
Sensitivity, specificity, NPV and PPV of PECARN in identifying traumatic brain injury on cranial CT.
Diagnostic accuracy of each of the CDRs when applied to those patients attending with head injury who do not meet the specific individual inclusion and exclusion criteria.
Rule performance in patients with bleeding diathesis, ventriculoperitoneal shunt, non-accidental injuries and pre-existing neurological conditions.
Economic evaluation of financial savings or burden of implementing each CDR.
Rate of prolonged symptoms following a non-severe head injury.
Patient recruitment, study procedure and data collection
Patients with head injuries will be identified at the ED triage desk using electronic alerts and visual reminders for patients who receive a head injury type injury code. Triage nurses will attach a clinician study clinical report form (CRF) to the patient record. Patients will be enrolled in the study by the treating clinician. Verbal consent for participation will be sought and documented by the treating clinician; consent for participation will include permission to telephone families 14–90 days after the ED visit for follow-up. Consent will be sought at the time of the initial ED visit. Should the parent or guardian of the child not be available at that time, we will seek consent for involvement in the study either during the in-patient stay (where admitted) or at the time of telephone follow up (where discharged from ED). Identification of missed eligible patients will be undertaken by the research assistant in each participating centre through a review of the daily ED attendance record.
Data collected by the ED treating clinicians will include the predictor variables from the three CDRs (CATCH , PECARN , CHALICE ). The initial ED assessment data will be documented prior to management decisions.
A separate CRF will be completed by the site research assistant during the hospital stay (in admitted patients) or after ED discharge (in those patients discharged direct from ED) once outcome data are available. It will collect the following parameters: detailed demographics, time lines (times of triage, clinician evaluation, ED and hospital discharge), ED observation and duration of observation, admission status and duration of admission, intensive care admission, intubation and ventilation and duration of ventilation, imaging and results, neurosurgical interventions and mortality.
The telephone follow-up to screen for possible initially missed intracranial injuries will be completed by the research assistant or the site physician investigators 14–90 days after the injury if no cranial CT is performed. Data on ongoing signs and symptoms, neuroimaging, admission and neurosurgery will be elicited. Six contact attempts will be made. If more than 90 days have elapsed from the time of injury, or if there have been six failed contact attempts, the patient follow up will be regarded as unsuccessful and the patient deemed lost to follow up.
All study materials have been piloted at a single site (Royal Children’s Hospital Melbourne) ; modification of the materials to comply with local patient flow and administrative requirements have been assessed and approved by the study steering committee.
CRFs will be de-identified after all data points have been completed and any data queries have been addressed. Data collation and analysis will take place at the central study site (Murdoch Childrens Research Institute, Melbourne).
All participating clinicians (physicians and nurse practitioners) at all sites receive formal training in the completion of the clinician CRF prior to the commencement of the study. Research assistants collecting data on the accompanying CRFs undergo formal training at the central site prior to the commencement of the study. Standardised teaching materials have been created and provided to participating sites. The study coordinator will ensure that all staff have received appropriate orientation and training and will ensure compliance with study protocol through site visits. Investigators and research assistants are not blinded to the results of the collected outcome data.
Determination of outcome
Consultant radiologist reports of CTs.
Operative reports for those who required neurosurgical intervention.
Review of medical record for the duration of admission and secondary outcomes.
Structured telephone follow up at 14–90 days post injury for patients discharged without neuroimaging.
Patients for whom final outcome data are not available will be excluded from data analysis.
This process will permit the identification of the presence and extent of injury allowing classification as per the definitions of each head injury CDR.
Further definitions used:
ED observation: Ongoing clinical assessment and observation of the patient in ED for less than 6 hours post initial clinical assessment.
Admission: Transfer from ED to a hospital inpatient unit (including short stay, observation, or intensive care unit) for longer than 6 hours.
Neurosurgical interventions will be categorised based on operative reports into the following categories: Dura repair of cerebrospinal fluid leaks, skull fracture elevation, haematoma drainage, intracranial pressure (ICP) monitoring, lobectomy, tissue debridement, ventriculostomy, other.
Head imaging (CT and magnetic resonance imaging) will be categorised as follows based on reports by consultant radiologists: Cerebellar haemorrhage, cerebral contusion, cerebral oedema, cerebral haemorrhage, intracerebral haematoma, diastasis of the skull, extradural/epidural haematoma, extra-axial haematoma, intraventricular haemorrhage, midline shift/shift of brain structures, pneumocephalus, skull fracture (and depth of depression), subarachnoid haemorrhage, subdural haematoma, traumatic infarction.
When applying each CDR, items will be scored as present, absent or unknown. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of each of the CDRs will be calculated using the definitions and parameters set out in the derivation studies as published [11, 16, 17]. In addition, the two CDRs limited to minor head injuries (CATCH and PECARN) will also be applied to patients of all head injury severities to assess their performance in this extended patient group. Likewise, the CHALICE CDR, though derived for all severities of head injury, will undergo separate analysis in minor head injury to allow comparison of performance accuracy of the three CDRs in that population. Performance accuracy will also be calculated in patient subgroups including but not restricted to patients with bleeding diathesis and ventriculoperitoneal shunts. Rates of secondary outcomes such as cranial CT, neurosurgical intervention, ciTBI and CSII and missed ciTBI and CSII will be calculated. Key percentages will be presented with 95% confidence intervals. Data will be entered using Epidata (The Epidata Association, Odense, Denmark) and analysed using Stata 12 (Statacorp, College Station, Texas, USA).
Sample size and power calculation
In deriving a sample size for patient subgroups we extrapolated from the PECARN data as it is the only CDR which differentiates between children aged less than two years and children aged two years and older .
Projected sensitivity for outcomes of clinically important traumatic brain injury (ciTBI), need for neurosurgery and brain injury on computed tomography (CT) based on PECARN data
Number of patients predicted
Projected performance of CDR in predicting outcome (sensitivity)
95% confidence interval
Need for neurosurgery
Brain injury on CT
Ethical issues and consent
In this observational non-interventional study parental verbal consent and participant verbal assent (for patients deemed capable to understand and appropriately answer questions) will be obtained for all patients; it will include permission to conduct a follow-up telephone call to determine outcome. Delayed consent at the time of the phone call if necessary has been approved for patients not enrolled during the initial ED visit. Ethics approval has been granted at all 10 study sites.
Patients who refuse consent or withdraw will continue to be managed as per the treating clinician.
As this is an observational study we are not anticipating adverse events.
Ideally, all patients with head injuries would receive a cranial CT to determine the presence or absence of significant intracranial injuries. However, this would expose a large number of patients to unnecessary CTs and the associated cancer related risks; therefore, similar to the methodology used in the derivation and validation studies for CATCH  and PECARN  this study relies on patient follow up by telephone. In doing so we will establish whether a relevant outcome has occurred or not.
CT rates in Australia and New Zealand may be lower [23, 25] than in North America and as reported for the CATCH and PECARN studies [8, 10, 11, 17] and higher than the baseline rates reported from the United Kingdom in the CHALICE study . This highlights one of the potential key strengths of this study as it tests the CDRs in a setting different to that in which each one was derived. Finally, while we were provided with copies of the telephone follow up questionnaires used by the CATCH and PECARN investigators (personal communication, Dr Martin Osmond and Dr Nathan Kuppermann) we reconstructed the predictor variables for the three CDRs solely from the published papers [11, 16, 17]. This may have introduced an element of interpretation in terms of the most precise wording to be used in a clinical emergency setting.
This study will allow the simultaneous comparative application and validation of three major paediatric head injury clinical decision rules outside their derivation setting. In addition to a high recruitment rate, the study will depend on high follow up rates to ensure that our results accurately represent the whole population of children presenting with head injuries.
We have so far recruited more than 10,000 of the planned 20,000 patients. We will complete recruitment by the end of 2014.
Children’s head injury algorithm for the prediction of important clinical events
Canadian assessment of tomography for childhood head injury
Pediatric emergency care applied research network
Clinically significant intracranial injury
Clinically important traumatic brain injury
Clinical decision rule
Negative predictive value
Positive predictive value.
We would like to thank participating families, emergency department staff and the site research assistants. The study is funded by grants from the National Health and Medical Research Council (project grant GNT1046727, Centre of Research Excellence for Paediatric Emergency Medicine GNT1058560), Canberra, Australia; the Murdoch Childrens Research Institute, Melbourne, Australia; the Queensland Emergency Medicine Research Foundation (EMPJ-11162), Brisbane, Australia; Perpetual Philanthropic Services (2012/1140), Australia; Auckland Medical Research Foundation (No. 3112011) and the A + Trust (Auckland District Health Board), Auckland, New Zealand; WA Health Targeted Research Funds 2013, Perth, Australia; the Townsville Hospital and Health Service Private Practice Research and Education Trust Fund, Townsville, Australia; and the Victorian Government’s Infrastructure Support Program, Melbourne, Australia. FEB’s time was part funded by a grant from the Murdoch Children’s Research Institute. SRDs time was part funded by the Health Research Council of New Zealand (HRC13/556).
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