Prospective evaluation of indirect costs due to acute rotavirus gastroenteritis in Spain: the ROTACOST study
- Marta Bouzón-Alejandro†1, 3,
- Lorenzo Redondo-Collazo1, 2, 3,
- Juan Manuel Sánchez-Lastres3, 4,
- Nazareth Martinón-Torres1, 2, 3,
- José María Martinón-Sánchez1, 2, 3,
- Federico Martinón-Torres†1, 2, 3Email author and
- the ROTACOST research team5
© Bouzón-Alejandro et al; licensee BioMed Central Ltd. 2011
Received: 30 November 2010
Accepted: 14 September 2011
Published: 14 September 2011
The effect of rotavirus in developed countries is mainly economic. This study aimed to assess the indirect costs induced by rotavirus acute gastroenteritis (RVAGE) in Spain.
A prospective observational study was conducted from October 2008 to June 2009. It included 682 children up to 5 years of age with acute gastroenteritis (AGE) who attended primary care (n = 18) and emergency room/hospital settings (n = 10), covering the regions of Galicia and Asturias (North-west Spain). All non-medical expenses incurred throughout the episode were recorded in detail using personal interviews and telephone contact.
Among the 682 enrolled children, 207 (30.4%) were rotavirus positive and 170 (25%) had received at least one dose of rotavirus vaccine. The mean (standard deviation) indirect cost caused by an episode of AGE was estimated at 135.17 (182.70) Euros. Costs were 1.74-fold higher when AGE was caused by rotavirus compared with other etiologies: 192.7 (219.8) Euros vs. 111.6 (163.5) Euros (p < .001). The costs for absenteeism were the most substantial with a mean of 91.41 (134.76) Euros per family, resulting in a loss of 2.45 (3.17) days of work. In RVAGE patients, the absenteeism cost was 120.4 (154) Euros compared with 75.8 (123) for the other etiologies (p = .002), because of loss of 3.5 (3.6) vs 1.9 (2.9) days of work (p < .001). Meals costs were 2-fold-higher (48.5 (55) vs 24.3 (46) Euros, p < .001) and travel costs were 2.6-fold-higher (32 (92) vs 12.5 (21.1) Euros, p = .005) in RVAGE patients compared with those with other etiologies. There were no differences between RVAGE and other etiologies groups regarding costs of hiring of caregivers or purchase of material. Patients with RVAGE were admitted to hospital more frequently than those with other etiologies (47.8% vs 14%, p < .001).
Rotavirus generates a significant indirect economic burden. Our data should be considered in the decision-making process of the eventual inclusion of rotavirus vaccine in the national immunization schedule of well developed countries.
Rotavirus is the leading cause of acute gastroenteritis (AGE) in infants and children under 5 years of age, causing 600,000 deaths worldwide . In developed countries, death by rotavirus is very rare, but infection by rotavirus is an important cause of morbidity, and it represents a high cost. At the age of 5 years, almost all children will have suffered an episode of acute rotavirus gastroenteritis (RVAGE), 1 of each 5 will need a visit to the physician, 1 of 65 will be hospitalized and approximately 1 of 293 will die [1–5]. In the last 20 years, the mortality rates by rotavirus have decreased in the more developed countries, but improvement in hygienic-healthy conditions has not modified the global incidence of the disease, and therefore, vaccination is the most efficacious measure to prevent this illness [6–9].
In the USA, it has been estimated that rotavirus infections generate direct sanitary costs of 250 million of dollars per year and the indirect costs are more than a billion dollars. Despite the fact that rotavirus gastroenteritis is currently considered to be the most common pediatric disease in the European Community preventable by vaccination, specific data about the indirect economic burden generated by rotavirus in Europe is limited [7, 10–15]. In Spain, economic data on rotavirus are even more scarce, and its impact in terms of indirect costs is almost unknown [6, 16–20]. The REVEAL study considered both direct and indirect costs, and compiled data from 7 countries including Spain . Another single centre hospital-based study performed by our group showed that the indirect costs generated by RVAGE were 2.6-fold higher than those induced by other etiologies [18, 19].
The aim of the ROTACOST study was to prospectively determine the indirect economic burden of AGE caused by rotavirus in a broad population including not only hospital-care but also emergency and primary care settings.
A prospective, observational multicentric study was conducted from October 2008 to June 2009 using a pediatric research network (ROTACOST study group -ReGALIP - http://www.regalip.org) that included primary, emergency and hospital care settings. Any patient up to 5 years old seeking care because of an AGE episode was considered eligible for the study if they fulfilled the following conditions: a) 3 or more bowel motions less consistent than usual, associated or not associated with vomiting, in a 24-hour period; b) symptoms must have occurred within 7 days of enrollment, preceded by a 14-day symptom-free period; and c) an episode of AGE must not have occurred in the 2 weeks prior to the onset of current symptoms. All nonmedical expenses from the start to the end of the diseases were recorded in detail using personal interviews and telephone contact. A fecal immunoassay for rotavirus detection in a fecal sample was performed in all included patients (VIKIA Rota-Adeno®, Biomerieux). This study was approved by the reference ethics committee, Comité Etico de Investigación de Galicia (ref 2009/039). All parents or guardians received information about the study and signed an informed consent before study entry.
Clinical, epidemiological and economic data were recorded and uploaded through a specific web site. The data collection was performed in 2 phases: first, personally during a contact visit; and second, by either phone or a planned visit once the acute episode had finished. During the first contact, the parents received specific information and guidance for data collection until the second survey/visit.
Methods to estimate indirect expenses
Estimated cost of work lost was calculated by the following order: (a) using the exact amount, if the person interviewed knew the exact rate per hour, (b) based on the annual/monthly/weekly earnings, the mean amount earned per hour, considering the numbers of hours worked per week, and the number of hours lost, and (c) based on the Spanish minimum mandatory salary for the year 2008 (Royal Decree 1763/2007), i.e., 28.42 Euros per day. Both spouses were considered if they both worked.
Any journey to the physician's office, hospital, pharmacy, or related to or caused by the child's condition was considered. Distance traveled was registered, and the cost of traveling by car was calculated by applying article 8.A.2 of the Regulations of the Personal Income Tax, approved by the Royal Decree 1775/2004, which sets a cost of 0.19 Euros per kilometer traveled.
This included day nursery or caregiver expenses, but only when contracted for care of the other siblings.
Expenses incurred by meals outside the home because of the disease of the child. The number of meals and the cost per meal were recorded.
This included any expenses derived from the purchase of oral rehydration or similar solutions, antidiarrheal agents or other drugs prescribed by the physician, additional number of diapers used and their cost, specific special diets (e.g., lactose-free), topical creams, or any other materials purchased during the time of the disease that were adequately explained by the parent or guardian.
When appropriate, data are presented as mean (standard deviation). Patients were divided into "rotavirus acute gastroenteritis" (RVAGE) and "other etiologies" groups for comparison purposes. Normal distribution of the data was assessed with the Kolmogorov-Smirnov test, and the Mann-Whitney or Student's t test was used accordingly. Multiple linear regression analysis was performed to adjust for the effect of the etiology (rotavirus vs another etiology), admission, age and sex of patients in the generated costs. A value of p < 0.05 was considered significant. Statistical analyses were performed using SPSS version 17.0 (SPSS Inc., Chicago Illinois, USA).
Summary of patient characteristics
GLOBAL (All etiologies)
(n = 682)
Gastroenteritis by rotavirus
(n = 207)
Gastroenteritis by other etiologies
(n = 428)
Sex (male %)
Rotavirus vaccination (complete or partial vaccination)
Maximum number of depositions in 24 hours
6.9 ± 3.4 (6.0)
8.0 ± 4.0 (7.0)
6.3 ± 3.0 (6.0)
Number of times needed medical care
2.1 ± 1.2 (2.0)
2.3 ± 1.3 (2.0)
2.0 ± 1.2 (2.0)
Gastroenteritis episode duration (days)
7.3 ± 3.5 (7.0)
7.6 ± 2.9 (7.0)
7.2 ± 3.7 (6.0)
Length of hospital stay (days)
4.4 ± 2.1 (4.0)
4.5 ± 2.1 (4.0)
4.4 ± 2.1 (4.0)
Mean ± SD (Median)
Mean ± SD (Median)
Mean ± SD (Median)
N° of hours of lost work
19.60 ± 25.36 (10)
28.1 ± 28.9 (20)
15.6 ± 22.9 (8)
N° of days of lost work
2.45 ± 3.17 (1,25)
3.5 ± 3.6 (2.5)
1.9 ± 2.9 (1)
91.41 ± 134.76 (40)
120.4 ± 154.1 (72.5)
75.8 ± 123.3 (28.4)
N° of Kms.
56.08 ± 113.46 (20)
79.3 ± 158.7 (26.5)
46.7 ± 92.8 (18)
Costs of travelling (€)
18.66 ± 55.30 (7)
32.1 ± 92.1 (14.8)
12.5 ± 21.1 (5)
14.70 ± 41.40 (0)
14.8 ± 44.4 (0)
15.7 ± 41.4 (0)
N° of meals outside home
5.47 ± 7.46 (2)
8.2 ± 7.8 (6)
4.1 ± 7.1 (1)
Cost meals (€)
33.33 ± 51.35 (10)
48.5 ± 55.9 (40)
24.3 ± 46.8 (0)
34.4 ± 30.7 (27,7)
34.3 ± 25.9 (28.4)
34.0 ± 33.5 (27.0)
Oral Serum (€)
9.88 ± 9.95 (8,90)
10.2 ± 12.3 (8.5)
9.7 ± 9.03 (8.6)
Special milk (€)
11.52 ± 21.01 (3,15)
10.2 ± 18.9 (0)
12.6 ± 23.3 (3.3)
3.46 ± 5.21 (0)
3.5 ± 5.8 (0)
2.7 ± 4.6 (0)
Extra diapers (€)
11.89 ± 12.70 (10)
12.3 ± 9.7 (10)
11.2 ± 14.1 (8.5)
4.43 ± 6.38 (3)
3.2 ± 4.4 (0)
4.9 ± 7.1 (3)
Other materials (€)
7.0 ± 12.74 (2,53)
6.01 ± 10.1 (0)
7.8 ± 4.1 (3)
Other expenses (€)
14.34 ± 92.43 (0)
12.1 ± 39.3 (0)
17.3 ± 19.5 (0.8)
TOTAL INDIRECT COSTS (€)
135.17 ± 182.70 (67)
192.7 ± 219.8 (99,5)
111.6 ± 163.5 (54,3)
Indirect costs were also significantly higher in hospitalized patients compared with those in non-hospitalized patients (293.4 [261.2] Euros vs 85.5 [110.4] Euros, p < .001).
The ROTACOST study showed that there is an outstanding burden generated by AGE in the North-west of Spain in terms of indirect costs, mainly because of the absenteeism of parents. When rotavirus is the etiological agent, costs are 75% higher compared with those for other etiologies, and these costs account for one third of the Spanish minimum official salary.
Few previous studies in this setting were prospective, focused on indirect costs and included all types of patients from primary care to hospital care [18–21]. Only Lee et al. have compiled such a comprehensive collection of indirect costs in the USA setting . The REVEAL study assessed both the direct and the indirect costs of RVAGE in 3 different health care settings (hospital, emergency department, and primary care) . Absenteeism costs were also the highest in every country surveyed in the REVEAL study, as a consequence of a variable work loss that ranged from 2.3 days in France to 7.5 days in the United Kingdom. Other studies with similar objectives excluded 25% to 80% of the expenses sources taken into account in these 3 studies [22–25].
Prior to rotavirus vaccine availability in Spain, we performed a study with the same methodology as the current study but restricted it to one single centre . We found that rotavirus cases accounted for 60% of the total cases and an event of RVAGE was estimated to cost €427, twice the cost of an episode due to any other etiology. The differences between our previous study and the present study may be mainly related to the implementation of rotavirus vaccine and an actual decline in the number and severity of RVAGE cases. In addition, less severe patients have been now included through the primary care recruiting network.
According to recent epidemiological data regarding rotavirus disease in Spain, approximately 310,000 cases of rotavirus-induced diarrhea occur every year in children under 5 years of age, causing 14,000 hospitalizations [16, 17, 26, 27]. Consistent with our study, only the indirect costs of rotavirus in patients requiring hospital admission would amount to €3 million every year. A recently published model of a universal rotavirus vaccination program applied to Spain using cost data consistent with our study, showed that more than 136,000 cases of RVAGE and €60 million (€38 from a societal perspective) in expenses could be avoided per birth cohort .
The main limitations in our study are those common to multicentric and economical studies based on the survey approach. Differences in methodology prevented direct comparison with some other studies mainly because of not including/specifying all the sources detailed in our study. Previous experience of the main team with the same protocol , appropriate training of the participating subinvestigators and a very conservative approach applied are indicative that the obtained results are reliable and demonstrative -if not under-estimative- of the actual burden of rotavirus in terms of indirect costs.
In conclusion, rotavirus disease represents a significant economic burden in terms of indirect costs in our country. This fact reinforces the interest of rotavirus vaccination in developed countries and it should be taken into account in the assessment and decision-making process of the inclusion of rotavirus vaccine into national immunization programs
Acknowledgements and Funding
The ROTACOST research team is composed of the following members of the Galician Pediatric Research Network ReGALIP-http://www.regalip.com: S. Almeida Agudín, F. Álvarez García, E. Álvarez Garnelo, A. Amado Puentes, A.G. Andrés Andrés, J. Ares Álvarez, C. Astorgano Fernández, C. Baza Vilariño, M. Boullosa Estévez, M. Busto Cuiñas, M. Caamaño González, I. Carballeira González, MªA. Carballo Silva, A. Castellón Gallego, P. Crespo Suárez, I. del Río Pastoriza, Mª V. González Conde, N. Fernández Martínez, M.A. Fernández Pérez, C. García Sendón, M. Kamal Kdamel, P. Lago Mandado, A. Lía Taborda, M°C. López del Olmo, M. López Franco, M. López Sousa, P. Martínez Abad, R. Miguélez Díaz, C. Molinos Norniella, M°C. Murias Taboada, F.A. Ordóñez Álvarez, E. Pérez Gómez, A. Pérez López, M. Portugueses de la Red, V. Rodríguez de la Rúa Fernández, J. Rodríguez Suárez, M. Sampedro Campos, G. Suárez Otero, I. Torre Rodríguez, and F. Vadillo González. Further details may be obtained at http://www.rotacost.org and http://www.regalip.com.
We would like to thank Sonia Pertega Diaz and Maria Teresa Seoane Pillado for their assistance in the statistics of the manuscript. The ROTACOST study group research activities were supported by grants from Consellería de Economía e Industria/Xunta de Galicia (Promoción Xeral de Investigación 10PXIB918184PR), Consellería de Sanidade/Xunta de Galicia (RHI07/2-intensificación actividad investigadora and PS09749), Fundación de Investigación Médica Mutua Madrileña, Sanofi Pasteur MSD, Instituto Carlos III (Intensificación de la actividad investigadora), Fondo de Investigación Sanitaria (FIS; PI070069) del plan nacional de I+D+I and 'fondos FEDER' given to Federico Martinon-Torres. These funds were applied in the development and maintenance of the collaborative network, purchase of fungible material and Vikia tests®, sample management, and bioinformatics related to this publication.
- Parashar UD, Hummelman EG, Bresee JS, Miller MA, Glass RI: Global illness and death caused by rotavirus disease. Emerg Infect Dis. 2003, 12: 304-306.View ArticleGoogle Scholar
- Cunliffe NA, Kilgore PE, Bresee JS, Steele AD, Luo N, Hart C: Epidemiology of rotavirus in Africa: review to assess the need for rotavirus immunization. Bull World Health Organ. 1998, 76: 525-537.PubMedPubMed CentralGoogle Scholar
- Bern C, Martines J, de Zoysa I, Glass RI: The magnitude of the global problem of diarrhoeal disease: a ten year update. Bull World Health Organ. 1992, 70: 705-714.PubMedPubMed CentralGoogle Scholar
- De Zoysa I, Feachen RG: Intervention for the control of diarrhoeal disease among young children. Bull World Health Organ. 1985, 63: 569-583.PubMedPubMed CentralGoogle Scholar
- Kosek M, Bern C, Guerrant RL: The global burden of diarrhoeal, as estimated from studies published between 1992 and 2000. Bull World Health Organ. 2003, 81: 197-204.PubMedPubMed CentralGoogle Scholar
- Giménez Sánchez F, Martinón Torres F, Bernaola Iturbe E, Baca Cots M, de Juan Martín F, Díez Delgado J, Garcés Sánchez M, Gómez Campderá JA, Picazo J, Pineda Solas V: The role of the rotavirus vaccine in childhood vaccination schedules. An Pediatr (Barc). 2006, 64: 573-577. 10.1157/13089923.View ArticleGoogle Scholar
- Soriano-Gabarró M, Mrukowicz J, Vesikari T, Verstraeten T: Burden of rotavirus disease in European Union countries. Pediatr Infect Dis J. 2006, 25: S7-S11. 10.1097/01.inf.0000197622.98559.01.View ArticlePubMedGoogle Scholar
- Glass RI: The promise of new rotavirus vaccines. N Engl J Med. 2006, 354: 75-77. 10.1056/NEJMe058285.View ArticlePubMedGoogle Scholar
- Lepage P: Rotavirus infection in Europe: time for effective prevention?. Pediatr Infect Dis J. 2006, 25 (1 Suppl): S5-S6.View ArticlePubMedGoogle Scholar
- Mrukowicz JZ, Krobicka B, Duplaga M, Kowalska-Duplaga K, Domañski J, Szajewska H, Kantecki M, Iwañczak F, Pytrus T: Epidemiology and impact of rotavirus diarrhoea in Poland. Acta Paediatr. 1999, 88: 53-60.View ArticleGoogle Scholar
- Vesikari T, Rautanen T, Von Bonsdorff CH: Rotavirus gastroenteritis in Finland: burden of disease and epidemiological features. Acta Paediatr Suppl. 1999, 426: 24-30.View ArticleGoogle Scholar
- Rheingans RD, Heylen H, Giaqinto C: Economic of rotavirus gastroenteritis and vaccination in Europe. Pediatr Infect Dis J. 2006, 25: S48-S55. 10.1097/01.inf.0000197566.47750.3d.View ArticlePubMedGoogle Scholar
- Fruhwirth M, Berger K, Ehlken B, Moll-Schuler I, Brosl S, Mutz I: Economic impact of community- and nosocomially acquired rotavirus gastroenteritis in Austria. Pediatr Infect Dis J. 2001, 20: 184-188. 10.1097/00006454-200102000-00013.View ArticlePubMedGoogle Scholar
- Takala AK, Koskenniemi E, Joensuu J, Makela M, Vesikari T: Economic evaluation of rotavirus vaccinations in Finland: randomized, double-blind, placebo-controlled trial of tetravalent rhesus rotavirus vaccine. Clin Infect Dis. 1998, 27 (2): 272-282. 10.1086/514650.View ArticlePubMedGoogle Scholar
- Floret D, Lina B, Pinchinat S, Billaud G, Aït-Belghiti F, Largeron N, Bellemin B, Trang CN, Fau C, Gaspard C, Mamoux V, Marcelon L: Epidemiology and burden of rotavirus diarrhea in day care centers in Lyon, France. Eur J Pediatr. 2006, 165 (12): 905-6. 10.1007/s00431-006-0187-z.View ArticlePubMedGoogle Scholar
- Gil A, Carrasco P, Jiménez R, San-Martín M, Oyagüez I, González A: Burden of hospitalizations attributable to rotavirus infection in children in Spain, period 1999-2000. Vaccine. 2004, 22: 2221-2225. 10.1016/j.vaccine.2003.11.037.View ArticlePubMedGoogle Scholar
- Gil de Miguel A, Carrasco Garrido P, Esteban Hernández J, San-Martín Rodríguez M, González López A: Burden of hospitalizations attributable to rotavirus infection in children in the Autonomous Region of Madrid, Spain, period 1999-2000. An Pediatr (Barc). 2006, 64: 530-535. 10.1157/13089917.View ArticleGoogle Scholar
- Martinón-Torres F, Bouzón-Alejandro M, López-Sousa M, Redondo-Collazo L, Almeida-Agudín S, Astorgano-Fernández C, Martinón-Sánchez J: An estimation of indirect costs caused by acute rotavirus gastroenteritis in a Galician area, Spain. Eur J Pediatr. 2008, 167: 337-339. 10.1007/s00431-007-0466-3.View ArticlePubMedGoogle Scholar
- Lopez-Sousa M, Bouzón-Alejandro M, Martinón-Torres F: Rotavirus and its indirect costs. An Pediatr (Barc). 2008, 69 (1): 89-90. 10.1157/13124225.View ArticleGoogle Scholar
- Giaquinto C, Van Damme P, Huet F, Gotheforrs L, Van der Wielen M, on behalf of the REVEAL study Group: Costs of Community-Acquired Pediatric Rotavirus Gastroenteritis in 7 European Countries: The REVEAL Study. J Infect Dis. 2007, 195: S36-S44. 10.1086/516716.View ArticlePubMedGoogle Scholar
- Lee BP, Azimi PH, Staat MA, Louie L, Parada E, Berke T, Ward RL, Bernstein DI, Matson DO: Nonmedical costs associated with rotavirus disease requiring hospitalization. Pediatr Infect Dis J. 2005, 24: 984-988. 10.1097/01.inf.0000183754.29707.cd.View ArticlePubMedGoogle Scholar
- Griffiths RI, Anderson GF, Powe NR, Oliveras E, Herbert RJ, Grant CC, Davidson BL: Economic impact of immunization against rotavirus gastroenteritis. Evidence from a clinical trial. Arch Pediatr Adolesc Med. 1995, 149: 407-414.View ArticlePubMedGoogle Scholar
- Liddle JL, Burgess MA, Gilbert GL, Hanson RM, McIntyre PB, Bishop RF, Ferson MJ: Rotavirus gastroenteritis: impact on young children, their families and the health care system. Med J Aust. 1997, 167: 304-307.PubMedGoogle Scholar
- Roberts JA, Cumberland P, Sockett PN, Wheeler J, Rodrigues LC, Sethi D, Roderick PJ, Infectious Intestinal Disease Study Executive: The study of infectious intestinal disease in England: socio-economic impact. Epidemiol Infect. 2003, 130: 1-11. 10.1017/S0950268802007690.View ArticlePubMedPubMed CentralGoogle Scholar
- Tucker AW, Haddix AC, Bresee JS, Holman RC, Parashar UD, Glass RI: Cost-effectiveness analysis of a rotavirus immunization program for the United States. JAMA. 1998, 279: 1371-1376. 10.1001/jama.279.17.1371.View ArticlePubMedGoogle Scholar
- Díez-Domingo J, Martín IO, SAnz AB, López AG, Martínez CC, Boronat CP: Rotavirus gastroenteritis among children under five years of age in Valencia, Spain. Pediatr Infect Ds J. 2006, 25: 455-457. 10.1097/01.inf.0000217378.30444.21.View ArticleGoogle Scholar
- Diez-Domingo J, Lara Suriñach N, Malé Alclade N, Betegón L, Largeron N, Trichard M: Burden of paediatric rotavirus gastroenteritis (RVGE) and potential benefits of a universal rotavirus vaccination programme with a pentavalent vaccine in Spain. BMC Public Health. 2010, 10: 469-10.1186/1471-2458-10-469.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2431/11/81/prepub